We always make our halfway stop in Manchester whenever we travel between London and Scotland and when we do, we often stay at the Macdonald Manchester Hotel & Spa. The hotel is part of the Macdonalds chain of luxury hotels and as such has very spacious rooms, several homely offerrings and ensuite bathrooms. It is only just a few minutes walk from Piccadilly train station and a few more walking from the bus station. The hotel has different styles of rooms but the executive rooms which is what we stay in as they are spacious enough for a family of 4 have amazing views overlooking the mancunian highway and of the city.
I have family in Manchester but the draw for us is the complimentary package which gives access to the hotels thermal suite which has a sensation shower, both an infra red sauna and a hot rock sauna, the scented steam room and an ice igloo at no added cost to the regular room booking price.